CD8B Antikörper (FITC)

Produktnummer ABIN951409

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD8B in FACS. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für CD8B Antikörper (FITC) (ABIN951409)

Target: CD8B (CD8b Molecule (CD8B))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8B Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: 03-04-01

Produktdetails anti-CD8B Antikörper (FITC)

Spezifität: This monoclonal antibody reacts with the beta chain of the CD8 differentiation antigen. The 3.4.1 antibody also blocks both activation in an allogenic response and cell mediated cytotoxicity by CD8 T cells.

Kreuzreaktivität (Details): Species reactivity (tested):Rat.

Aufreinigung: Protein G Chromatography of Ascites fluid.

Immunogen: Rat/mouse T cell hybrids expressing CD8. Remarks: Donor: BALB/c mouse spleen cells. Fusion Partner: X63 Ag.653 myeloma cell line.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD8B

Target: CD8B (CD8b Molecule (CD8B))

Andere Bezeichnung: CD8 beta

Hintergrund: CD8b is expressed on most thymocytes and mature T cytotoxic/suppressor cells (MHC class I restricted). While the CD8a and CD8b form a heterodimer on the surface of thymocytes and thymus-dependent T cytotoxic/suppressor cells, the majority of NK cells, many CD8 T cells from athymic rats, many activated CD4 T cells, and intestinal epithelium lymphocytes (IEL) express CD8a without CD8b. This suggests that expression of the CD8 heterodimer (a/b) is more dependant on intrathymic T cell maturation than that of the homodimer (a/a). The thymus dependence of CD8a/b T cells may be due to a requirement for thymic selection on self MHC class I antigens.Synonyms: CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain

Gen-ID: 24931

NCBI Accession: NP_113727

UniProt: P05541

Pathways: T-Zell Rezeptor Signalweg